Hand eczema and other inflammatory skin diseases: efficacy of oral alitretinoin
نویسندگان
چکیده
منابع مشابه
Hand eczema and other inflammatory skin diseases: efficacy of oral alitretinoin
Background Alitretinoin is a vitamin A derivative. It’s a pan-agonist of Retinoic Acid Receptors and Retinoid X Receptors. It interferes with keratinocytes’ proliferation and differentiation and exerts immunomodulatory and anti-inflammatory activity. Its clinical efficacy in the treatment of chronic hand eczema is well demonstrated. Recently, various case reports and case series pointed out its...
متن کاملAlitretinoin – its use in intractable hand eczema and other potential indications
Chronic hand eczema is a significant cause of morbidity. A number of treatments are traditionally used, and often useful, but in spite of this a sizeable group of patients develop chronic recalcitrant hand eczema. Retinoids are known to influence keratinization and inflammation, and acitretin has shown some effect in the treatment of chronic hand eczema. Alitretinoin (9-cis-retinoic acid) is a ...
متن کاملAlitretinoin for the treatment of chronic hand eczema: clinical rationale
2014 Chronic hand eczema (CHE), an inflammatory skin disease, places heavy psychosocial and economic burden on the affected individual and society as a whole. Patch testing is recommended to identify potential causative allergens in each patient. Efficacy of traditional topical treatments render the management of CHE challenging. Oral alitretinoin (9-cis-retinoic acid) is a new drug for the tre...
متن کاملEfficacy and Safety of Alitretinoin for Chronic Hand Eczema in Korean Patients
BACKGROUND Chronic hand eczema (CHE) tends to be refractory to conventional therapy. Previous clinical trials have found that a 24-week treatment course of oral alitretinoin is effective and well tolerated for CHE treatment. OBJECTIVE The aim of this study was to investigate the efficacy and safety of oral alitretinoin in Korean CHE patients. METHODS A total of 27 patients with moderate to ...
متن کاملAlitretinoin for the treatment of severe chronic hand eczema
This paper presents a summary of the evidence review group (ERG) report into the clinical effectiveness and cost-effectiveness of alitretinoin for the treatment of adults with severe chronic hand eczema refractory to topical steroid treatment in accordance with the licensed indication, based upon the evidence submission from Basilea Pharmaceuticals Ltd to the National Institute for Health and C...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical and Translational Allergy
سال: 2015
ISSN: 2045-7022,2045-7022
DOI: 10.1186/2045-7022-5-s1-o23